JOURNAL 1104


Bioorganic & Medicinal Chemistry Reports
VOLUME & ISSUE
Year: 2018 Issue: 1 January-December
PAGES
p.22 - 28
STATISTICS
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AUTHORS
  • Züleyha Kudaş
PDF OF ARTICLE

GRAPHICAL ABSTRACT


ABSTRACT


A novel tyrosine kinase inhibitor, regorafenib was electrochemically studied using a GC disc electrode in non-aqueous media. A well-resolved, irreversible, diffusion-controlled oxidation peak was obtained at 1.55 V in acetonitrile solution containing 0.1 M TBAClO4. Experimental conditions such as scan rate, indicate that two electrons play a role in the electrochemical oxidation of regorafenib. The recommended method was successfully applied to the determination of regorafenib in drug capsules.

KEYWORDS
  • Regorafenib
  • cyclic voltammetry
  • electrochemical oxidation