JOURNAL


Bioorganic & Medicinal Chemistry Reports
VOLUME & ISSUE
Year: 2018 Issue: 1 January-December
PAGES
p.6 - 15
STATISTICS
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AUTHORS
  • Esen Yıldız Bekfelavi
  • Pınar Küce Çevik
  • Özgür Yılmaz
  • Nermin Şimşek Kuş
  • Gökhan Coral
  • Ayla Çelik
PDF OF ARTICLE

ABSTRACT


The electrophilic addition of bromine to bicyclo[4.2.0]oct-3-en-7-one in CHCl3 at 0 oC led to 80% yield of trans- and 10% yield of cis-dibromide. The structure of the synthesized molecules was determined using 1H and 13C NMR spectra. The biological activity of cis- and trans-dibromide was investigated in terms of antibiotic and toxic effects at cellular level. Cis- and trans-dibromide showed antibiotic activity and it was tested in two different living systems (prokaryotic and eukaryotic) in terms of biological lymphocyte culture assay. The toxic effects of cis- and trans-dibromide were measured at cellular level by mitotic index as the cell kinetic parameter in a peripheral lymphocyte culture assay.

KEYWORDS
  • Dibromoketone
  • biological activity
  • antibiotic effect
  • toxic effect
  • mitotic index

SUPPORTING INFORMATION


Supporting Information
Download File 2-BMCR-1811-1035-SI.pdf (1.06 MB)