JOURNAL 1356


Records of Natural Products
VOLUME & ISSUE
Available Online: November 23,2019
PAGES
p.1 - 6
DOI ADDRESS
http://doi.org/10.25135/rnp.157.1907.1356
(DOI number will be activated after the manuscript has been available in an issue.)
STATISTICS
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AUTHORS
  • Ting-ting Lin
  • Gang Chen
PDF OF ARTICLE

GRAPHICAL ABSTRACT


ABSTRACT


A new sesquiterpene (1) and nine known alkaloids (2-10) were isolated from the roots of Toddalia asiatica. The structure of compound 1 were resolved by NMR and HRESI data, as well as ECD calculation for determining the absolute configuration. The known compounds were identified to be 8-acetonyldihydronitidine (2), 8-acetonyldihydroavicine (3), dihydronitidine (4), oxynitidine (5), decarine (6), skimmianine (7), g-fagarine (8), N-methylflindersine (9), and 4-methoxy-N-methyl-2-quinolone (10) by comparing the NMR data with those in the literature. Compound 1 is the first eremophilane-type sesquiterpenoid isolated from this species. The known compounds 2, 3, and 6 were discovered for the first time from the genus Toddalia. All the isolated compounds were evaluated for their inhibitory effects against phosphodiesterase-4, as result, compound 2 showed strong inhibitory effect against phosphodiesterase-4 with an IC50 value of 5.14 mM.

KEYWORDS
  • Toddalia asiatica
  • sesquiterpene
  • alkaloids
  • phosphodiesterase-4

SUPPORTING INFORMATION


Supporting Information
Download File 157-RNP-1907-1356-SI.pdf (933.45 KB)