JOURNAL 1406


Records of Natural Products
VOLUME & ISSUE
Available Online: October 14,2019
PAGES
p.1 - 6
DOI ADDRESS
http://doi.org/10.25135/rnp.153.19.09.1406
(DOI number will be activated after the manuscript has been available in an issue.)
STATISTICS
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AUTHORS
  • Kiem Van Phan
  • Nguyen Thi Mai
  • Hoang Thi Tuyet Lan
  • Bui Thi Mai Anh
  • Vu Van Doan
  • Bui Huu Tai
  • Nguyen Xuan Nhiem
PDF OF ARTICLE

GRAPHICAL ABSTRACT


ABSTRACT


A new sesquiterpene, schisandrathera E (1) and seven dibenzocyclooctadiene lignans as schisantherin D (2), schisantherin B (3), tigloylgomisin P (4), schisphenin E (5), angeloylgomisin H (6), (+)-deoxyschizandrin (7), and (+)-gomisin K3 (8) were isolated from the leaves of Schisandra sphenanthera Rehder & E.H.Wilson. Their structures were elucidated by spectroscopic and mass spectrometric analyses, including 1D-, 2D-NMR, HR-ESI-MS and ECD spectra. Compound 1 displayed moderate cytotoxicity against both PC3 and MCF4 cell lines in MTT assay with IC50 values of 22.60 and 7.80 µM, respectively.

KEYWORDS
  • Schisandra sphenanthera
  • schisandrathera E
  • sesquiterpene
  • dibenzocyclooctadiene

SUPPORTING INFORMATION


Supporting Information
Download File 153-RNP-1909-1406-SI.pdf (1.49 MB)