Glycerol as an alternative green medium for carbonyl compound reductions

Original Article

JOURNAL 151

Organic Communications

VOLUME & ISSUE

Year: 2009 Issue: 2 April-June

PAGES

p.34 - 41

STATISTICS

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AUTHORS

Adi Wolfson and Christina Dlugy

GRAPHICAL ABSTRACT

ABSTRACT

Glycerol was employed as an alternative green reaction medium in various carbonyl reduction methodologies. The high polarity of glycerol allowed for the simple reduction of different carbonyl compounds with sodium borohydride and the enantioselective reduction of ethyl acetoacetate with both Ru-BINAP and baker's yeast. As a solvent, glycerol also allowed electro-reduction and microwave assisted reactions.

KEYWORDS

Asymmetric hydrogenation
glycerol
green chemistry
metal hydride
reduction