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Synthesis and biological studies of novel 2-(4-substitutedbenzyl-thio)-5-amino-6-(benzo[d]thiazol-2-yl)-7-(4- chlorophenyl)pyrido--[2,3-d]-pyrimidin-4(3H)-one derivatives

Original Article

JOURNAL 177

Organic Communications
VOLUME & ISSUE
Year: 2011 Issue: 2 April-June
PAGES
p.33 - 41
STATISTICS
Viewed 1903 times.
AUTHORS
    M. Suresh, P. Lavanya, K. Naga Raju, Sreekanth B. Jonnalagaddaand C. Venkata Rao
PDF OF ARTICLE

GRAPHICAL ABSTRACT

ABSTRACT

A series of novel 2-(4-substitutedbenzylthio)-5-amino-6-(benzo[d]thiazol-2-yl)-7-(4-chlorophenyl)pyrido[2,3-d]pyrimidin-4(3H)-one derivatives were synthesized and evaluated for their antibacterial and antifungal activity. All the derivatives were efficiently synthesized in four steps. The structure of the newly synthesized compounds was elucidated by their IR, 1H-NMR, 13C NMR, LCMS mass spectra and elemental analysis.

 KEYWORDS
  • 2-(4-substitutedbenzylthio)-5-amino-6-(benzo[d]thiazol-2-yl)-7-(4-chlorophenyl)pyrido[2
  • 3-d]-pyrimidin-4(3H)-one
  • antibacterial
  • antifungal.