JOURNAL 184


Organic Communications
VOLUME & ISSUE
Year: 2011 Issue: 3 July-September
PAGES
p.67 - 74
STATISTICS
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AUTHORS
    Chinthaparthi Radha Rani, Gangireddy Chandra Sekhar Reddy, Chereddy Syama Sundar, Kunda Uma Maheswara Rao, Krishnammagari Suresh Kumar and Cirandur Suresh Reddy
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GRAPHICAL ABSTRACT


ABSTRACT


A new series of 3-thio-1,5-dihydro-2,4,3-benzodioxaphosphepin-3-amino acid esters (4a-k) were synthesized by treating different amino acid ester hydrochlorides (3a-k) with phosphorus monochloride intermediate (2) which was previously formed in situ from 1,2-phenylenedimethanol (1) and thiophosphoryl chloride in the presence of triethylamine in dry tetrahydrofuran (THF) at 0-5 ºC to room temperature. The structures of the title compounds (4a-k) were established by analytical, IR, NMR (1H, 13C and 31P) and mass spectra, and they have been screened for their antimicrobial activity. They exhibited significant antibacterial, and antifungal activity.

KEYWORDS
  • Phosphoramides
  • 1
  • 2-phenylenedimethanol
  • amino acid hydrochloride
  • antibacterial activity
  • antifungal activity