JOURNAL 195


Organic Communications
VOLUME & ISSUE
Year: 2013 Issue: 1 January-March
PAGES
p.47 - 54
STATISTICS
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AUTHORS
    Yellajyosula L N Murthy, Rama Mohana Rao Saviri, Atchuta Ramaiah Parimi and Saranapu Nareesh
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GRAPHICAL ABSTRACT


ABSTRACT


A series of substituted 6-aryl 5-cyano 2-uracil and 6-aryl 5-cyano 2-thiouracils (1a-1l) were achieved by the reaction of various aldehydes, ureas, thioureas and ethylcyanoacetate using Magnesium methoxide as a versatile catalyst. All compounds were screened for antibacterial and antifungal activities against 6 strains Bacillus substilis , Streptococcus spPseudomas aeruginosaKlebsiella pneumoniaeCandida albicansAspergillus nigermicroorganisms using Muller-Hinton broth method. Some of the prepared compounds exhibited promising activities when compared to the standard Linezolid & Amphotercine-B.

KEYWORDS
  • Magnesium methoxide
  • oxo/thio uracil derivatives
  • antimicrobial activity
  • methodology.