JOURNAL 676


Organic Communications
VOLUME & ISSUE
Year: 2014 Issue: 1 January-March
PAGES
p.28 - 33
STATISTICS
Viewed 2188 times.
AUTHORS
    J. Kranthi Kumar and A. Venkat Narsaiah
PDF OF ARTICLE

GRAPHICAL ABSTRACT


ABSTRACT


A simple and efficient asymmetric synthesis of (S,S)-Ethambutol has been carried out using a chiral butanediol. The synthesis was completed within six steps with an overall yield 53% and the enantiomeric purity of final product was 98%. All the reactions were very clean and the yields are excellent.

KEYWORDS
  • Ethambutol
  • butanediol
  • protection
  • tuberculosis
  • oxalylchloride
  • reduction