JOURNAL 767


Organic Communications
VOLUME & ISSUE
Year: 2015 Issue: 1 January-March
PAGES
p.1 - 8
STATISTICS
Viewed 2121 times.
AUTHORS
    Samia Guezane Lakoud, Marc Lecouvey, Houria Berrebah and Nour-Eddine Aouf
PDF OF ARTICLE

GRAPHICAL ABSTRACT


ABSTRACT


Three chiral phosphonoacetamides were prepared by an alternative method . For this purpose, 2-(diethoxyphosphoryl)acetic acid was prepared from ethyl 2-bromoacetate by treatment of P(OEt) 3 followed by saponification of the ester with K 2CO 3. BOP activated amidation of the 2-(diethoxyphosphoryl)acetic acid with (S)-amino acids gave the corresponding phosphonoaceteamides. Growth inhibition of two phosphonoacetamides on Paramecium sp. were studied.

KEYWORDS
  • Paramecium sp
  • Organophosphorus
  • Phosphonoacetamide
  • phosphorylation
  • coupling reaction