JOURNAL 778


Organic Communications
VOLUME & ISSUE
Year: 2015 Issue: 4 October-December
PAGES
p.98 - 108
STATISTICS
Viewed 2051 times.
AUTHORS
    Venkataramireddy Veeramreddy, Tejeswararao Allaka, Jayashree Anireddy and Ravi Varala
PDF OF ARTICLE

GRAPHICAL ABSTRACT


ABSTRACT


The Click reaction between the electronically divergent triazole compounds 4-((l-(4-(tert-butyl)benzyl)-1H-l,2,3-triazol-4-yl)methoxy)-5-methoxy-2-nitrobenzamides (8a-e) with different aldehydes using Na 2S 2O 4 in DMSO was performed to obtain hybrid of quinazolinone-triazole derivatives (10a-o). All the synthesized compounds were fully characterized on the basis of their detailed spectral studies and screened for their antibacterial activities strains using paper disc method. The compounds (10 a-o) were evaluated for their antibacterial activity against human pathogenic organism Escherichia ColiStaphylococcus aureus (Table 1). The investigation of antibacterial screening data reveal that 10e10f10g10jand 10n were highly active against E. coli, where as 10b10d10j,10k and 10o showed least activity. Compounds 10b10e10f10g10i10k and 10n showed high activity against S. aureus, where as compounds 10d10j10o showed least activity. Compounds 10c10h10l and 10o were inactive against both organisms employed.

KEYWORDS
  • The Click reaction
  • methoxyquinazolinone-triazole
  • reductive cyclization

SUPPORTING INFORMATION


Supporting Information
Download File 13-OC-1505-375_SI.pdf (6.57 KB)