JOURNAL 808


Organic Communications
VOLUME & ISSUE
Year: 2017 Issue: 2 April-June
PAGES
p.90 - 98
STATISTICS
Viewed 1904 times.
AUTHORS
    Gökçe Demir, Meliha Burcu Gürdere, Mustafa Ceylan and Yakup Budak
PDF OF ARTICLE

GRAPHICAL ABSTRACT


ABSTRACT


The 1,1'-(5,5'-(1,3-phenylene)bis(3-aryl-4,5-dihydro-1H-pyrazole-5,1-diyl))di-ethanone (5a-e) and 1,3-bis(1-phenyl-3-(aryl)-4,5-dihydro-1H-pyrazol-5-yl)benzene (6a-e) were synthesized by addition of hydrazine hydrate and/or phenylhydrazine to 1,3-phenylene-bis-chalcone derivatives (3a-e), respectively. The structures of obtained compounds (5a-e and 6a-e) were characterized using the spectroscopic methods (NMR, IR) and elemental analysis. Addition, the in vitroantibacterial activities of compounds (5a-e) was tested against the five human pathogenic bacteria. Gentamycin and Fluconazole were used as positive control. The results were given as inhibition zone (mm) and the compounds 5d and 5e showed the same activity with standard (Fluconazole) against C. albinas.

KEYWORDS
  • 1
  • 3-Phenylene-b is-N-acetylpyrazoles
  • 1
  • 3-phenylene-bis-N-phenylpyrazoles
  • antibacterial activity

SUPPORTING INFORMATION


Supporting Information
Download File 12-OC-1612-453-SI.pdf (1.6 MB)