Synthesis and biological activities of some new spiro 1,2,4-triazole derivatives having sulfonamide moiety

Original Article

JOURNAL 825

Organic Communications

VOLUME & ISSUE

Year: 2017 Issue: 4 October-December

PAGES

p.280 - 287

DOI ADDRESS

http://doi.org/10.25135/acg.oc.27.17.08.046

STATISTICS

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AUTHORS

Hany M. Dalloul, Khaled El-nwairy, Ali Z. Shorafa and Ahmed Abu Samaha

GRAPHICAL ABSTRACT

ABSTRACT

A new series of spiro 1,2,4-triazoles 5-9a-j were prepared by the reaction of appropriate amidrazones 4 with cyclic ketones in catalytic amount of p-toluene sulfonic acid. The structures of the titled compounds have been elucidated by the elemental analysis and spectroscopic data (IR, 1H NMR, 13C NMR and MS). The biological activities of the prepared compounds were investigated using well-established methods from the literature.

KEYWORDS

Amidrazone
nitrilimines
spiro 1
2
4-triazole
sulfonamide
cyclic ketone