JOURNAL 1352


Organic Communications
VOLUME & ISSUE
Year: 2019 Issue: 3 July-September
PAGES
p.169 - 175
STATISTICS
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AUTHORS
  • Oxana Kazakova
  • Liudmila Rubanik
  • Irina Smirnova
  • Olga Savinova
  • Anastasiya Petrova
  • Nikolay Poleschuk
  • Elmira Khusnutdinova
  • Eugene Boreko
  • Yuliya Kapustina
PDF OF ARTICLE

GRAPHICAL ABSTRACT


ABSTRACT


Modified synthesis of 3β-nicotinoyloxy-olean-12(13)-en-28-oic acid and 3-deoxy-3a-homo-3a-aza-28-hydroxy-olean-12(13)-en from natural occurring oleanolic acid is suggested. These compounds and two others of ursane and lupane type triterpenoids (3-oximino-urs-12-en-28-oic acid and 3-deoxy-3a-homo-3a-aza-28-hydroxy-lup-12(13)-en) were screened in vitro against Chlamydia trachomatis strain F-3271/Belarus/2015. Oleanane triterpenoids became the leading compounds with chemotherapeutic index > 8 and were chosen for further research.


 
KEYWORDS
  • synthesis
  • triterpenoids
  • oleanane
  • ursane
  • Chlamydia trachomatis

SUPPORTING INFORMATION


Supporting Information
Download File 66-OC-1907-1352-SI.pdf (321.68 KB)