JOURNAL 1327


Organic Communications
VOLUME & ISSUE
Available Online: October 24,2019
PAGES
p.1 - 7
DOI ADDRESS
http://doi.org/10.25135/acg.oc.66.19.07.1327
(DOI number will be activated after the manuscript has been available in an issue.)
STATISTICS
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AUTHORS
  • Hülya Çelik
  • Müslüm Kuzu
PDF OF ARTICLE

GRAPHICAL ABSTRACT


ABSTRACT


IIn this study, some Schiff base derivatives (6a-f) were synthesized using a microwave method. The synthesized compounds were characterized by 1D, 2D NMR and mass spectral data. Their inhibitory effects were studied on carbonic anhydrase isozymes (hCA I and II), purified from human erythrocyte cells by Sepharose-4B-L-tyrosine-sulfanilamide affinity chromatography and the compounds N-3-Methylbenzylidene-4-fluoroaniline (6b), N-4-Methylbenzylidene-4-fluoroaniline (6c), N-2-Methoxybenzylidene-4-fluoroaniline (6d)  showed moderate activity on hCAII in the range of IC50 values.

KEYWORDS
  • Schiff base
  • carbonic anhydrase
  • N-benzylideneaniline
  • NMR
  • HRMS

SUPPORTING INFORMATION


Supporting Information
Download File 66-OC-1907-1327-SI.pdf (1.33 MB)