JOURNAL 6


Records of Natural Products
VOLUME & ISSUE
Year: 2007 Issue: 4 November-December
PAGES
p.44 - 50
STATISTICS
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AUTHORS
    Sema Çarıkçı, Çiğdem Çöl, Turgut Kılıç, Akın Azizoğlu
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GRAPHICAL ABSTRACT


ABSTRACT


Four known ent-kaurene diterpenoids 1-4 were isolated from the acetone extract of Sideritis tmolea P. H. Davis by using different chromatographic methods . The structures of the isolated compounds were determined as siderol (ent-7α-acetoxy-18-hydroxy-kaur-15-ene) (1), 7-acetoxysideroxol (ent-7 a -acetoxy-18-hydroxy-15 b ,16 b -epoxykaurane) (2)ent-7α,15β,18-trihydroxykaur-16-ene (3) and ent-7α-acetoxy-15β,18-dihydroxykaur-16-ene (4) by using IR, NMR ( 1H, 13C, APT and DEPT) techniques and mass spectroscopy. The antimicrobial and antituberculous activities of the acetone and methanol extracts and compound 1 have been reported.

KEYWORDS
  • Lamiaceae
  • Sideritis tmolea
  • Kaurene
  • Diterpenoids
  • Antimicrobial activity