JOURNAL 17


Records of Natural Products
VOLUME & ISSUE
Year: 2008 Issue: 3 July-September
PAGES
p.76 - 82
STATISTICS
Viewed 1842 times.
AUTHORS
    Amani, S. Awaad, Nawal H. Mohamed, Derek. J. Maitland and Gamal A. Soliman
PDF OF ARTICLE

GRAPHICAL ABSTRACT


ABSTRACT


Five main flavonoid glycosides were isolated, for the first time, from the ethanol extract of Desmostachia bipinnata (L.)Stapf ( Gramineae ). They were identified as kaempferol(1), quercetin(2), quercetin-3-glucoside(3), trycin(4) and trycin-7-glucoside(5). The structure elucidation was based on UV, Electrospray ionization mass spectrometry (ESIMS), 1H and 13C NMR, proton- proton correlation spectroscopy ( 1H- 1H Cosy), distortionless enhancement by polarization transfer (DEPT), heteronuclear single quantum coherence (HSQC), and heteronuclear multiple bond correlations spectrum (HMBC). The total extract (200 and 300 mg/kg) and two of the isolated compounds (trycin and trycin-7-glucoside.100 mg/kg each) showed a very promising antiulcerogenic activity with curative ratios; 68.31, 70.54, 77.39 and 78.93%, respectively.

KEYWORDS
  • Antiulcerogenic
  • Desmostachia bipinnata (L.)Stapf
  • quercetin-3-glucoside
  • quercetin and trycin-7-glucoside