JOURNAL 20


Records of Natural Products
VOLUME & ISSUE
Year: 2008 Issue: 4 October-December
PAGES
p.100 - 106
STATISTICS
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AUTHORS
    Olapeju O. Aiyelaagbe and James B. Gloer
PDF OF ARTICLE

GRAPHICAL ABSTRACT


ABSTRACT


A new aliphatic acid named japodic acid (1) with a gem-dimethyl cyclopropane ring has been isolated from the roots of Jatropha podagrica. Its structure was established by 1D and 2D NMR and mass spectrometric data. Two other known compounds, erythrinasinate (2) and fraxidin (3) were also isolated from this plant for the first time. Japodic acid showed mild insect growth inhibition activity against Helicoverpa zea (37% growth reduction at 100 ppm). Fraxidin and erythrinasinate exhibited antibacterial activity against Bacillus subtilis while japodic acid was inactive in the antibacterial assays conducted.

KEYWORDS
  • Jatropha podagrica
  • aliphatic acid
  • antibacterial activity
  • Japodic acid
  • Insect growth inhibition activity.