JOURNAL 291


Records of Natural Products
VOLUME & ISSUE
Year: 2010 Issue: 1 January-March
PAGES
p.72 - 78
STATISTICS
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AUTHORS
    Moses S. Owolabi, Akintayo Ogundajo, Kamil O. Yusuf, Labunmi Lajide, Heather E. Villanueva, Jessika A. Tuten, and William N. Setzer
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GRAPHICAL ABSTRACT


ABSTRACT


 The essential oil from the dried leaves of Chromolaena odorata (L.) R.M. King & H. Rob. was obtained by hydrodistillation and analyzed by gas chromatography-mass spectrometry (GC-MS).  The major components were α-pinene (42.2%), β-pinene (10.6%), germacrene D (9.7%), β-copaen-4α-ol (9.4%), (E)-caryophyllene (5.4%), and geijerene/prejeigerene (7.5%).  The oil was screened for antimicrobial activity and showed antibacterial activity against Bacillus cereus (MIC = 39 μg/mL) and antifungal activity against Aspergillus niger (MIC = 78 μg/mL). DFT (B3LYP/6-31G*) and post-HF (MP2/6-311+G**) indicate that pregeigerene is less stable (0.45 and 3.99 kcal/mol, respectively) than its Cope rearrangement product geigerene.

KEYWORDS
  • Chromolaena odorata
  • Eupatorium odoratum
  • Asteraceae
  • essential oil
  • pinene
  • germacrene D