JOURNAL 447


Records of Natural Products
VOLUME & ISSUE
Year: 2012 Issue: 1 January-March
PAGES
p.71 - 74
STATISTICS
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AUTHORS
    Nurgün Küçükboyacı, Semiha Özkan and Fatma Tosun
PDF OF ARTICLE

GRAPHICAL ABSTRACT


ABSTRACT


Alkaloid profile of the aerial parts of Genista sandrasica Hartvig & Strid. (Fabaceae) growing in Turkey was studied by capillary gas chromatography-mass spectrometry (GC-MS). Ten quinolizidine alkaloids were identified in the alkaloid extract of G. sandrasica . The main alkaloids were: sparteine (13.68%), N-acetylcytisine (6.48%), 13-methoxylupanine (13.12%), anagyrine (40.49%) and baptifoline (10.76%). In addition, antibacterial and antifungal activities of the alkaloid extract of G. sandrasica were tested against standard strains of the bacteria (Escherichia coli , Pseudomonas aeruginosaBacillus subtilis and Staphylococcus aureus) as well as the fungi (Candida albicans and Candida krusei). The alkaloid extract of G. sandrasica showed significant activity against B. subtilis and S. aureus with minimum inhibitory concentrations (MIC) of 31.25 and 62.5 µg/mL.

KEYWORDS
  • Genista sandrasica
  • Fabaceae
  • alkaloids
  • GC-MS
  • antimicrobial activity.