JOURNAL 720


Records of Natural Products
VOLUME & ISSUE
Year: 2014 Issue: 2 April-June
PAGES
p.83 - 92
STATISTICS
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AUTHORS
    Seema Begum, Mumtaz Ali, Abdul Latif, Waqar Ahmad, Sultan Alam, Muhammad Nisar, Muhammad Zeeshan, Mahmud Tareq Hassan Khan, Farzana Shaheen and Manzoor Ahmad
PDF OF ARTICLE

GRAPHICAL ABSTRACT


ABSTRACT


Two new lycoctonine type C19-diterpenoid alkaloids, swatinine-A (1), and swatinine-B (2), along with four known C19-diterpenoid alkaloids, foresticine (3), neoline (4), delvestine (5), and chasmanine (6), were isolated from the aerial parts of the Aconitum laeve Royle. The structures of compounds 1 and 2 were deduced on the basis of spectroscopic techniques (EI-MS, HREI-MS, 1H NMR, 13C NMR, HMQC, and HMBC). Biological activities like inhibition of the multifunctional copper-containing enzyme tyrosinase, anti-oxidant and anti-inflammatory have also been carried out for all the compounds and reported herein. The structure-activity relationships for the inhibition of the enzyme tyrosinase by the compounds have been discussed.

KEYWORDS
  • Aconitum laeve Royle
  • C19-diterpenoids alkaloids chemistry
  • swatinine-A
  • swatinine-B
  • antioxidant
  • anti-inflammatory