JOURNAL 613


Records of Natural Products
VOLUME & ISSUE
Year: 2016 Issue: 6 November-December
PAGES
p.761 - 765
STATISTICS
Viewed 2015 times.
AUTHORS
    Sabrin R. M. Ibrahim, Gamal A. Mohamed, Lamiaa A. Shaala and Diaa T. A. Youssef
PDF OF ARTICLE

GRAPHICAL ABSTRACT


ABSTRACT


Calotroposide S (1), a new oxypregnane oligoglycoside has been isolated from the n-butanol fraction of Calotropis procera (Ait) R. Br. root bark. The structure of 1 was assigned based on various spectroscopic analyses. Calotroposide S (1) possesses the 12-O-benzoylisolineolon aglycone moiety with eight sugar residues attached to C-3 of the aglycone. It showed potent anti-proliferative activity towards PC-3 prostate cancer, A549 non-small cell lung cancer (NSCLC), and U373 glioblastoma (GBM) cell lines with IC 50 0.18, 0.2, and 0.06 µM, respectively compared with cisplatin and carboplatin.

KEYWORDS
  • Calotropis procera
  • Asclepiadaceae
  • calotroposide S
  • anti-proliferative activity

SUPPORTING INFORMATION


Supporting Information
Download File 89-RNP-1601-306-SI.pdf (875.34 KB)