JOURNAL 55


Records of Natural Products
VOLUME & ISSUE
Year: 2018 Issue: 3 May-June
PAGES
p.290 - 294
STATISTICS
Viewed 2001 times.
AUTHORS
    Pengxiang Lai , Huijuanzi Rao and Yang Gao
PDF OF ARTICLE

GRAPHICAL ABSTRACT


ABSTRACT


The essential oil of the aerial parts of Anthriscus caucalis M.Bieb was obtained by hydrodistillation and its components were analy z ed by using GC and GC-MS. Forty-six compounds representing 97.2% of the total oil were identified. The main constituents in the oil were identified as β-Bisabolene (28.4%), Germacrene D (18.9%), (Z, E)-α-Farnesene (16.8%) and γ-Muurolene (7.3%). I n vitro cytotoxicity evaluation against two cell lines of HepG2 (liver hepatocellular cells) and MCF-7 (human breast adenocarcinoma) cells showed a potent cytotoxic activity with the IC 50 values of 67.50 μg/mL and 55.83 μg/mL according to the MTT assay. Furthermore, t he essential oil exhibited a considerable activity against Bacillus subtilis and Escherichia coli with the MIC values of 0.095 mg/mL and 0.105 mg/mL tested by micro-dilution method . The antioxidant activity was evaluated by DPPH and FRAP methods, and the essential oil gave an IC 50 value of 0.451 mg/mL and a Trolox equivalent antioxidant concentration of 191.7 ± 11.3 μmol Trolox × g -1 in DPPH and FRAP, respectively. The results indicated that the essential oil was relatively active and may be useful in food and pharmaceuticals after more detailed study.

KEYWORDS
  • Anthriscus caucalis M. Bieb
  • essential oil
  • antioxidant activity
  • antibacterial activity
  • cytotoxic activity

SUPPORTING INFORMATION


Supporting Information
Download File 31-RNP-EO_1707-046_SI.pdf (177.08 KB)