JOURNAL 1647


Records of Natural Products
VOLUME & ISSUE
Year: 2020 Issue: 6 November-December
PAGES
p.410 - 415
STATISTICS
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AUTHORS
  • Nouran H. Abdel Fatah
  • Yhiya Amen
  • Fatma M. Abdel Bar
  • Ahmed F. Halim
  • Hassan-Elrady A. Saad
PDF OF ARTICLE

GRAPHICAL ABSTRACT


ABSTRACT


Our main objective in the present study was to search for bioactive compounds of potential antidiabetic and antioxidant activities from the methanol extract of Lactuca serriola L. aerial parts for the prevention and treatment of diabetes. Phytochemical investigation allowed the isolation of 17 known compounds identified based on various spectroscopic techniques as lupeol (1), β-sitosterol (2), taraxast-20-ene-3β,20-diol (3), glycerol monopalmitate (4) (2S,3S,4R,2`R,14E)-2-(2`-hydroxytetracosanoylamino)-14-octadecene-1,3,4-triol (5), lactucopicrin (6), daucosterol (7), (E)-p-coumaric acid (8), 11β,13-dihydrolactucin (9), 4-hydroxybenzoic acid (10), protocatechuic acid (11), kaempferol (12), quercetin (13), lactuside A (14), luteolin-7-O-β-D glucoside (15), lactuside B (16) and cichorioside B (17). The antioxidant activity was evaluated using ABTS, DPPH radical scavenging assays and FRAP assay. The ethyl acetate fraction showed remarkable α-glucosidase inhibitory activity (IC50, 9.16±0.17 µg/mL) and antioxidant activity among the tested fractions. The in vitro α-glucosidase inhibitory assay is reported in this study for the first time for L. serriola L. The results strongly suggest that L. serriola L. can be used as a potential good natural remedy targeting oxidative stress-related diabetes mellitus.

KEYWORDS
  • Asteraceae
  • Lactuca serriola
  • antioxidant
  • α-glucosidase inhibitors

SUPPORTING INFORMATION


Supporting Information
Download File A4-189-RNP-2005-1647-SI.pdf (3.22 MB)