Three New Polyketides from the Insect-Associated Fungus Letendraea sp. 5XNZ4-2

Original Article

JOURNAL 1786

Records of Natural Products

VOLUME & ISSUE

Year: 2021 Issue: 3 May-June

PAGES

p.187 - 193

DOI ADDRESS

http://doi.org/10.25135/rnp.206.20.08.1786

STATISTICS

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AUTHORS

Yan Xu
Nanyan Fu
Wanjing Ding
Pinmei Wang
Jinzhong Xu

GRAPHICAL ABSTRACT

ABSTRACT

Chemical investigation of the EtOAc extract of an insect-associated fungus Letendraea sp. 5XNZ4-2 cultured in Potato Dextrose Broth (1/2 PDB) medium lead to the isolation of three new polyketides, named letendronol D (1), phomopsiketones H-I (2-3). The structures of new compounds were elucidated by the analysis of HRESIMS and NMR spectroscopic data, and the absolute configurations were determined by modified Mosher’s method, ECD calculation and single-crystal X-ray diffraction. Cytotoxicity and antibacterial activities of 1 were assayed and regrettably 1 didn’t display any cytotoxicity and antibacterial activity. 3 was the first phomopsiketone derivative obtaining the lactone.

KEYWORDS

polyketides
insect-associated fungus
Letendraea sp.

SUPPORTING INFORMATION

Supporting Information

Download File A4-206-RNP-2008-1786-SI.pdf (3.31 MB)