(8S, 9R)-Dihydroisoflavipucine, a New Isoflavipucine Derivative from the Endophytic Fungi Botryosphaeria dothidea

Short Report

JOURNAL 2500

Records of Natural Products

VOLUME & ISSUE

Year: 2023 Issue: 2-March-April

PAGES

p.358 - 362

DOI ADDRESS

http://doi.org/10.25135/rnp.360.2206.2500

STATISTICS

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AUTHORS

Hui Chen
Wendan Li
Lian Xue
Xiuji Liu
Yiqing Zhou
Zhangshuang Deng

GRAPHICAL ABSTRACT

ABSTRACT

A new isoflavipucine derivative, (8S, 9R)-dihydroisoflavipucine (1), is isolated from an ethyl acetate extract of endophytic fungi Botryosphaeria dothidea (D4-2) derived from Taxus mairei. The structure of 1 is elucidated based on nuclear magnetic resonance, circular dichroism, and mass spectrometry. The antiproliferative activity of the isolates against breast cancer cells MDA-MB-231, MCF7 and 4T1 are evaluated.

KEYWORDS

Dihydroisoflavipucine
isoflavipucine
Taxus mairei
endophytic fungi
Botryosphaeria dothidea
antiproliferative activity

SUPPORTING INFORMATION

Supporting Information

Download File A15-360-RNP-2206-2500-SI.pdf (1.45 MB)