JOURNAL 2510
Records of Natural Products
VOLUME & ISSUE
Year: 2023 Issue: 2-March-April
Year: 2023 Issue: 2-March-April
PAGES
p.377 - 381
p.377 - 381
STATISTICS
Viewed 3373 times.
Viewed 3373 times.
GRAPHICAL ABSTRACT
ABSTRACT
A novel β-carboline, namely Plagranline A (1), and a known alkaloid (2) were isolated from the roots of Platycodon grandiflorus. Their structure was elucidated using a combination of spectroscopic analyses and computational chemistry, including electronic circular dichroism (ECD) and optical rotatory dispersion (ORD). Alkaloids 1 and 2 exhibited moderate inhibitory effects against NO production. Interestingly, 1 and 2 are the first alkaloid constituents reported from the plant P. grandifloras.
KEYWORDS- Platycodon grandiflorus
- β-carboline
- computational chemistry
- alkaloid
- anti-inflammatory activity
