A New Ergosterol-Type Steroid Isolated from the Nicotiana tabacum-Derived Endophytic Fungus Aspergillus sp. TE-65L

Short Report

JOURNAL 2909

Records of Natural Products

VOLUME & ISSUE

Year: 2023 Issue: 6 November-December

PAGES

p.1080 - 1084

DOI ADDRESS

http://doi.org/10.25135/rnp.420.2309.2909

STATISTICS

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AUTHORS

Xin-Rong Huang
Chao-Nan Jiang
Tong Si
Peng Zhang
Zhong-feng Zhang

GRAPHICAL ABSTRACT

ABSTRACT

Chemical study on the fungal strain Aspergillus sp. TE-65L, which was previously isolated from cultivated tobacco (Nicotiana tabacum L.), led to the production of four steroids including a new ergosterol-type steroid, namely aspergosterol A (1). Their chemical structures were established by detailed spectroscopic analysis of 1D/2D NMR and HRESIMS data. Compound 1 was found to possess anti-phytopathogenic activities against Alternaria alternate, Botrytis cinerea, and Fusarium oxysporum, with MIC values of 4, 8, and 16 μg/mL.

KEYWORDS

Aspergillus sp.
endophytic fungus
secondary metabolite
steroid
antifungal activity

SUPPORTING INFORMATION

Supporting Information

Download File A13-420-RNP-2309-2909-SI.pdf (1.06 MB)