9,11-Cycloneren-3,7-diol: a New Cyclonerane Sesquiterpene from the Marine-Sediment-Derived Fungus Trichoderma harzianum WH-22

Short Report

JOURNAL 3175

Records of Natural Products

VOLUME & ISSUE

Year: 2024 Issue: 3 May-June

PAGES

p.352 - 356

DOI ADDRESS

http://doi.org/10.25135/rnp.456.2403.3175

STATISTICS

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AUTHORS

Xin Dong
Lin-Chuan Jia
Hai-Quan Chai
Xiao-Xiao Liu
Lei Yang

GRAPHICAL ABSTRACT

ABSTRACT

One new cyclonerane sesquiterpene, 9,11-cycloneren-3,7-diol (1), along with four known ones, 11-cycloneren-3,7,10-triol (2), 9-cycloneren-3,7,11-triol (3), 11-methoxy-9-cycloneren-3,7-diol (4), and cyclonerodiol (5), were obtained from the extract of marine-derived fungus Trichoderma harzianum WH-22. The structure of 9,11-cycloneren-3,7-diol (1) was elucidated by comprehensive spectroscopic analysis, including 1D/2D NMR and HRESIMS data. 9,11-Cycloneren-3,7-diol (1) exhibited weak cytotoxicity against HeLa and HepG2 cancer cell lines with IC50 values of 68.2 and 59.7 μM, respectively.

KEYWORDS

Cyclonerane sesquiterpene
Trichoderma harzianum
structure elucidation
cytotoxic activity

SUPPORTING INFORMATION

Supporting Information

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