Isolation of New Secondary Metabolites from Kedrostis gijef and Evaluation of Their α-Glucosidase Inhibitory Activity

Original Article

JOURNAL 3236

Records of Natural Products

VOLUME & ISSUE

Year: 2024 Issue: 4 July-August

PAGES

p.393 - 404

DOI ADDRESS

http://doi.org/10.25135/rnp.468.2405.3236

STATISTICS

Viewed 1580 times.

AUTHORS

Mahmoud Mubarek
Fahd M. Abdelkarem
Ahmed Othman
Masako Matsumoto
Fangjing Li
Kuniyoshi Shimizu

GRAPHICAL ABSTRACT

ABSTRACT

Four new polyoxygenated cucurbitane triterpene glycosides named kedrojiftene A-D (4-7), were isolated via different chromatographic techniques along with three phenolic compounds (1-3) from the crude extract of Kedrostis gijef. The isolated compounds were elucidated based on 1D, 2D-NMR spectroscopic analyses, HRESIMS and comparison with the related metabolites in literature. In bioassay, the α-glucosidase inhibitory assay for the isolated compounds was carried out and compounds (1-3) showed significant inhibitory activities.

KEYWORDS

Kedrostis gijef
triterpene
cucurbitane
phenolic
α-glucosidase

SUPPORTING INFORMATION

identification cert

The plant identification cerificate issued by the Herbarium of the Desert Research Center

Download File plant Ident.pdf (396.2 KB)

Supporting Information

Download File A2-468-RNP-2405-3236-SI.pdf (7.6 MB)