JOURNAL 3265
Records of Natural Products
VOLUME & ISSUE
Year: 2024 Issue: 5 September-October
Year: 2024 Issue: 5 September-October
PAGES
p.520 - 525
p.520 - 525
STATISTICS
Viewed 1500 times.
Viewed 1500 times.
AUTHORS
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Trong Nghia Ngo
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Quoc Trung Nguyen
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Hoang Diem Ly
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Thi Hong Ngoc Dang
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Thi Kim Phung Nguyen
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Huynh Kim Yen
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Van Son Dang
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Thi Hong Tuoi Do
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Kim-dung Hoang
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Tan Phat Nguyen
GRAPHICAL ABSTRACT
ABSTRACT
One new 3-O-glycoside of betulinic acid, named heptaelliptoic acid A (1), together with one known betulinic acid analogue (2), and four other compounds (3‒6) were separated by combinatively chromatographic techniques. For the first time, all of the purified compounds (1‒6) were reported from the H. ellipticum species. Their structures were obviously elucidated basing exhaustive and pervasive UV-VIS, FT-IR, HR-MS-ESI, and NMR experiment data. Compounds 2-4 were significantly displayed the in vitro a-glucosidase inhibition (IC50 values of 11.53, 28.75, and 10.90 μM, respectively) better than the acarbose positive drug (IC50 value of 214.50 μM).
KEYWORDS- Araliaceae
- Heptapleurum ellipticum
- heptaelliptoic acid A
- α-glucosidase inhibition
- betulinic acid saponin
