JOURNAL 3301
Records of Natural Products
VOLUME & ISSUE
Year: 2024 Issue: 6 November-December
Year: 2024 Issue: 6 November-December
PAGES
p.610 - 617
p.610 - 617
STATISTICS
Viewed 1709 times.
Viewed 1709 times.
AUTHORS
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Ping Song
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Huazhen Li
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Pengxin Liu
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Tognqing Li
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Yan Guo
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Ping Zhao
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Shiwen Kang
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Xingzhou Yang
GRAPHICAL ABSTRACT
ABSTRACT
Two new isoflavones, caraganin E (1) and caraganin F (2), were purified from 75% ethanolic extract of Caragana jubata roots, in company with ten known compounds. The chemical structures of two novel isoflavones were elucidated by NMR, HR-ESIMS and circular dichroism (CD). GLUT4 translocation activity was tested in L6 cells for all isolated compounds. Among them, compound 5 exhibited the best activity, increasing the fluorescence intensity by 3.25 folds. The results of the exploration may help us understand the chemotaxonomic variety of natural products in Caragana jubata and enhance the diversity of flavonoids.
KEYWORDS- Caragana
- Caragana jubata
- flavonoids
- GLUT4 translocation
