JOURNAL 3339
Records of Natural Products
VOLUME & ISSUE
Year: 2024 Issue: 6 November-December
Year: 2024 Issue: 6 November-December
PAGES
p.699 - 704
p.699 - 704
STATISTICS
Viewed 1428 times.
Viewed 1428 times.
GRAPHICAL ABSTRACT
ABSTRACT
Chemical investigations on the culture of Penicillium oxalicum 2021CDF-3, a marine red alga-sourced endophytic fungus, revealed a new steroid, namely peniciloxatone A (1). With the aid of high-resolution electrospray ionization mass spectrometry (HRESIMS) and nuclear magnetic resonance (NMR) analyses, the structure of peniciloxatone A (1) was determined to be a polyoxygenated ergostane steroid. Cytotoxic activities of 1 were tested against A549, FADU, and HepG2 cells, and 1 was active against the FADU and HepG2 cells, with IC50 values of 9.5 ± 0.1 and 18.1 ± 0.3 μM, respectively.
KEYWORDS- Penicillium oxalicum
- secondary metabolites
- natural product
- steroid
- cytotoxicity
