JOURNAL 3427
Records of Natural Products
VOLUME & ISSUE
Year: 2025 Issue: 3 May-June
Year: 2025 Issue: 3 May-June
PAGES
p.286 - 290
p.286 - 290
STATISTICS
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Viewed 544 times.
GRAPHICAL ABSTRACT
ABSTRACT
Lignans, such as podophyllotoxin, schisandrin, and silymarin, are known for their notable biological activities. In our study, a new lignan, named melaleucin D (1), was isolated from the leaves and stems of the plant Melaleuca bracteata F. Muell. The planar structure was determined by combining 1H NMR/13C NMR/ COSY/HSQC/HMBC spectra and HRESIMS data. The absolute configuration was established by comparing the experimental circular dichroism (CD) data with the calculated theoretical ECD data. Compound 1 contained an unusual dioxane moiety. The antibacterial assay revealed that compound 1 did not exhibit a zone of inhibition against Staphylococcus aureus ATCC 6538 and Escherichia coli ATCC 25922 at a concentration of 256 mg/mL.
KEYWORDS- Melaleuca bracteata F. Muell.
- lignan
- separation
- structure elucidation
