JOURNAL 3518
Records of Natural Products
VOLUME & ISSUE
Year: 2025 Issue: 4 July-August
Year: 2025 Issue: 4 July-August
PAGES
p.559 - 564
p.559 - 564
STATISTICS
Viewed 776 times.
Viewed 776 times.
GRAPHICAL ABSTRACT
ABSTRACT
Notopterygium incisum is widely used in clinical practice because of its complex chemical composition and remarkable pharmacological effects. In this study, a previously undescribed lignan (1) was isolated from N. incisum. Its structure was evaluated through examinations of the NMR, HREIMS data and ECD calculation. Compound 1 demonstrated significant anti-inflammatory potential by inhibiting the secretion of nitric oxide (NO) in lipopolysaccharide (LPS)-induced macrophages, with an IC50 value of 3.57 μM.
KEYWORDS- Notopterygium incisum
- lignan
- anti-inflammatory activity
