Uvaol-28-D-(R)-pyroglutamic acid ester: a new triterpenoid compound from Circinellamuscae CGMCC 3.2695 and its activity assessment in transgenic zebrafish

Short Report

JOURNAL 3620

Records of Natural Products

VOLUME & ISSUE

Year: 2026 Issue: 1

PAGES

p.14 - 14

DOI ADDRESS

http://doi.org/10.25135/rnp.2508.3620

STATISTICS

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AUTHORS

Weiguan Chen
Xiaoli Zhang
Xiaoling Jin
Hao Li
Mahmut Miski
Xiaofang Tan

GRAPHICAL ABSTRACT

ABSTRACT

A novel triterpenoid compound named Uvaol-28-D-(R)-pyroglutamic acid ester (UPE) was obtained via microbial biotransformation of uvaol by Circinella muscae CGMCC 3.2695. Its structure was elucidated by spectroscopic and mass-spectrometric analyses, including 1D-, 2D-NMR and HR-ESI-MS. UPE administration promotes intersegmental vessel (ISV) growth and motor neuron development in transgenic zebrafish embryos in a concentration-dependent manner. Furthermore, UPE significantly restored the swimming distance in zebrafish exposed to combretastatin A-4 (CA-4), as assessed by ESOvision behavioral analysis. These findings suggest that UPE holds promise for the treatment of cardiovascular and cerebrovascular diseases.

KEYWORDS

Uvaol-28-D-(R)-pyroglutamic acid ester
Circinella muscae CGMCC 3.2695
transgenic zebrafish
intersegmental vessel
motor neuronal axonal

SUPPORTING INFORMATION

Supporting Information

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