Nicocembranoside A: A new neuroprotective cembrane glycoside from Nicotiana tabacum L.

Short Report

JOURNAL 3732

Records of Natural Products
VOLUME & ISSUE
Year: 2026 Issue: 3
PAGES
p.1 - 1
DOI ADDRESS
http://doi.org/10.25135/rnp.2511.3732
STATISTICS
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AUTHORS
  • Jun-Zhang Wu
  • Bao-Min Lin
  • Ping-Zhang Yao
  • Cui-Ling Chen
  • Miao Liang
  • Ya-Ke Luo
  • Pengfei Yang
  • Jun-Ping Gu
PDF OF ARTICLE

GRAPHICAL ABSTRACT

ABSTRACT

Cembrane-type diterpenoids are recognized for their medicinal significance.The phytochemical investigation of Nicotiana tabacum L. led to the isolation of Nicocembranoside A (1), a novel cembrane glycoside, represents the ninth naturally occurring cembrane glycoside and the first isolated from N. tabacum leaves. The structure of 1 was elucidated through  comprehensive spectroscopic analyses, including 1D (1H, 13C NMR) and 2D NMR (COSY, HSQC, HMBC, ROESY), complemented by HRESIMS and biosynthetic precedence. Additionally, seven known compounds were also isolated and characterized. Preliminary evaluation demonstrated 1 exhibits neuroprotective effect against glutamate-induced cytotoxicity
in PC12 cells at 10 μM.

 KEYWORDS
  • Nicotiana tabacum
  • cembrane glycoside
  • neuroprotective

SUPPORTING INFORMATION

Supporting Information
Download File RNP-2511-3732-SI.pdf (2.12 MB)