JOURNAL 3792
Records of Natural Products
Year: 2026 Issue: 4
p.4 - 4
Viewed 28 times.
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Chun-Xiao Chen
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Rong-Chun Qin
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Si-Ni Liu
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Meng Bai
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Zhen-Zhou Tang
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Hai-Mei Wei
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Cheng-Hai Gao
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Xin-Ya Xu
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Xiao-Dong Jiang
GRAPHICAL ABSTRACT
ABSTRACT
An in-depth investigation into the chemical constituents of Streptomyces ardesiacus GXIMD 03502, a strain known to produce 2-hydroxyphenylthiazoline derivatives, resulted in the isolation of a new α-pyrone compound, germicidin T (1), together with six known compounds (2–7). Their structures were elucidated using comprehensive spectroscopic analyses. The germicidin biosynthetic gene cluster was identified in the genome of this strain. Notably, ORF 17, a type III polyketide synthase (Germicidin synthase, GCS), was found to utilize trimethylmalonyl-ACP as a starter unit in the biosynthesis of compound 1. Based on this finding, the biosynthetic pathway for compounds 1–7 is proposed. Bioactivity evaluation revealed that all compounds exhibited weak toxicity against Artemia salina, while compounds 3 and 7 showed moderate anti-inflammatory activity.
KEYWORDS- Streptomyces ardesiacus
- α-pyrone
- germicidin
- trimethylmalonyl-ACP
- type III polyketide synthase
- biosynthesis
