An Undescribed Zhepiresionol Analogue from Ailanthus altissima

Short Report

JOURNAL 3520

Records of Natural Products
VOLUME & ISSUE
Available Online: July 28,2025
PAGES
p.1 - 6
DOI ADDRESS
http://doi.org/10.25135/rnp.538.2505.3520
(DOI number will be activated after the manuscript has been available in an issue.)
STATISTICS
Viewed 78 times.
AUTHORS
  • Yu-Ting Mu
  • Li Huang
  • Yi Li
  • Yun Deng
  • De-Feng Peng
PDF OF ARTICLE

GRAPHICAL ABSTRACT

ABSTRACT

This study involved the extraction, isolation, structural elucidation of a new analogue of zhepiresionol, as well as five lignans previously identified, from the plant Ailanthus altissima (Mill.) Swingle. The structural elucidation was accomplished through comprehensive analyses of various spectroscopic data, which included HRESIMS, UV, IR, and NMR, along with a comparison of ECD curves. At a concentration of 15 µM, Compound 1 showed the capacity to suppress IL-1β and IL-6 expression in RAW 264.7 cells that were Lipopolysaccharide-stimulated.

 KEYWORDS
  • Ailanthus altissima
  • zhepiresionol analogue
  • anti-inflammatory activity

SUPPORTING INFORMATION

Supporting Information
Download File 538-RNP-2505-3520-SI.pdf (851.09 KB)