Anti-inflammatory Diterpenoid Alkaloids from Aconitum taipeicum

Short Report

JOURNAL 3565

Records of Natural Products
VOLUME & ISSUE
Available Online: August 03,2025
PAGES
p.1 - 5
DOI ADDRESS
http://doi.org/10.25135/rnp.536.2506.3565
(DOI number will be activated after the manuscript has been available in an issue.)
STATISTICS
Viewed 51 times.
AUTHORS
  • Lanrun Yang
  • Yanni Liang
  • Dongbo Zhang
PDF OF ARTICLE

GRAPHICAL ABSTRACT

ABSTRACT

Aconitaimine A, a new hetidine-type C20-diterpenoid alkaloid (1), and three known aconitine-type C19-diterpenoid alkaloids (2-4) were isolated from the roots of Aconitum taipeicum. The structures of all isolates were identified by spectroscopic methods and comparison with literature data. Compounds 1 and 2 showed inhibition of nitric oxide production in RAW 264.7 macrophages stimulated by lipopolysaccharide with IC50 values of 30.5 and 4.7 μM compared to positive control (dexamethasone, IC50 = 12.9 μM).

 KEYWORDS
  • Aconitum taipeicum
  • Ranunculaceae
  • diterpenoid alkaloids
  • NO inhibitory activity

SUPPORTING INFORMATION

Supporting Information
Download File 536-RNP-2506-3565-SI.pdf (1.44 MB)