Cyclocarioside Z14, A New Dammarane Triterpenoid Glycoside from The Leaves of Cyclocarya paliurus with Cytotoxicity

Short Report

JOURNAL 3525

Records of Natural Products
VOLUME & ISSUE
Available Online: July 28,2025
PAGES
p.1 - 6
DOI ADDRESS
http://doi.org/10.25135/rnp.537.2505.3525
(DOI number will be activated after the manuscript has been available in an issue.)
STATISTICS
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AUTHORS
  • Yijin Xu
  • Ruotong Liu
  • Qian Yao
  • Xifan Wei
  • Lu Wang
  • Fei Cheng
PDF OF ARTICLE

GRAPHICAL ABSTRACT

ABSTRACT

A new dammarane triterpenoid glycoside cyclocarioside Z14 (1) and four known compounds (2-5) were isolated from the dichloromethane extract of the leaves of Cyclocarya paliurus. The chemical structures were elucidated by the extensive spectroscopic data analysis of NMR, HR-ESI-MS, and acid hydrolysis. All isolated compounds were assayed on the cytotoxicity against seven human cancer cell lines. The compounds 1 and 3 showed moderate cytotoxicity against MCF-7 cells with an IC50 value of 29.51 μM and 33.88 μM.

 KEYWORDS
  • Cyclocarya paliurus
  • dammarane triterpenoid glycoside
  • structural elucidation
  • cytotoxicity

SUPPORTING INFORMATION

Supporting Information
Download File 537-RNP-2505-3525-SI.pdf (1.41 MB)