JOURNAL 3506
Records of Natural Products
Available Online: May 29,2025
p.1 - 6
http://doi.org/10.25135/rnp.520.2504.3506 (DOI number will be activated after the manuscript has been available in an issue.)
Viewed 77 times.
GRAPHICAL ABSTRACT
ABSTRACT
Fusarium solani 2024f-xx, an endophytic fungus derived from the marine brown algae Sargassum thunbergii, was chemically studied. As a result, two polyhydroxy compounds, namely fusasolpolyol A (1) and (4E,8E,12E)-2,3,7,11-tetrahydroxy-2,4,6,8,10,12-hexamethyltetradeca-4,8,12-trienoic acid (2), as well as two known drimane-type sesquiterpenoids (3 and 4) were isolated and identified. The structures of the isolated compounds were ascertained by means of specific spectroscopic methods (mainly determined by HRESIMS and 1D/2D NMR data). Compound 1 was identified as a new compound. In the cytotoxic assays, compound 2 revealed moderate activity against the human gastric carcinoma cell MKN-45 and the human pancreatic cancer cell PATU8988T, with the respective IC50 values of 19.6 ± 1.2 μM and 26.3 ± 0.9 μM.
KEYWORDS- Fusarium solani
- endophytic fungus
- secondary metabolites
- polyhydroxy compound
- cytotoxic activity
