JOURNAL 3484
Records of Natural Products
Available Online: July 11,2025
p.1 - 6
http://doi.org/10.25135/rnp.531.2504.3484 (DOI number will be activated after the manuscript has been available in an issue.)
Viewed 119 times.
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Aalaa Salem
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Fatma Abdel Bar
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El-sayed M. Marwan
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Amal F. Soliman
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Saleh H. El-sharkawy
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Amira Mira
GRAPHICAL ABSTRACT
ABSTRACT
Nine known compounds were isolated from the fruitless bunches of Washingtonia filifera, an underutilized agricultural waste, using NMR and mass spectrometry. The identified compounds included β-sitosteryl oleate (1), oleic acid (2), β-sitosterol (3), threo-2,3-bis-(4-hydroxy-3-methoxyphenyl)-3-methoxypropanol (4), syringaresinol (5), diosmetin (6), tricin (7), daucosterol (8), and luteolin-7-O-β-D-glucoside (cynaroside) (9). In vitro acetylcholinesterase (AChE) inhibition assays revealed that compound 5 exhibited the strongest activity (IC50 = 29.75 µM), followed by compounds 4 and 6. Docking studies indicated significant interactions of the active compounds with key AChE residues, particularly Trp86 and Tyr341. ADME predictions further supported the drug-likeness of compounds 4 and 5. These results highlight the significance of W. filifera agricultural waste as a source of bioactive compounds, particularly with neuroprotective effects.
KEYWORDS- Washingtonia filifera
- California fan plam
- fruitless bunch
- acetylcholinesterase
- phenolics
- lignan
