JOURNAL


Records of Natural Products
VOLUME & ISSUE
Available Online: August 01,2019
PAGES
p.1 - 5
DOI ADDRESS
http://doi.org/10.25135/rnp.142.19.04.1264
(DOI number will be activated after the manuscript has been available in an issue.)
STATISTICS
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AUTHORS
  • Amira Elkattan
  • Ahmed Gohar
  • Mohamed Amer
  • Zain Naeem
  • Ahmed Ashour
  • Kuniyoshi Shimizu
PDF OF ARTICLE

ABSTRACT


The aim of this study was to discover more candidates for development of novel anti melanogenesis compounds from leaves of O. europeae. Seventeen compounds have been isolated from the leaves of O. europeae. The isolated compounds were identified as α, β-amyrin mixture (1), β-sitosterol (2), uvaol, erythrodiol mixture (3), oleanolic acid (4), maslinic acid (5), vomifoliol (6), β-sitosterol 3-O-β-D-glucoside (7), luteolin (8), oleoside dimethylester (9), oleuropein (10), hydroxypinoresinol 1-O-β-D-glucoside (11), luteolin-7-O-β-D-glucoside (12), diosmetin 7-O-β-D-glucoside (13), verbascoside (14), oleoside 11-methylester (15), secoxyloganin (16) and hydroxytyrosol 8-O-β-D-glucoside, hydroxytyrosol 4`-O-β-D-glucoside mixture (17). This is the first report on the identification of vomifoliol (6) in the oleaceae family. Results showed that several compounds other than oleuropein exhibited inhibition of melanin synthesis and at the same time with low cytotoxicity.

KEYWORDS
  • Olea europeae
  • Melanin
  • Vomifoliol

SUPPORTING INFORMATION


Supporting Information
Download File 142-RNP-1904-1264-SI.pdf (3.03 MB)