JOURNAL 2510


Records of Natural Products
VOLUME & ISSUE
Available Online: August 26,2022
PAGES
p.1 - 5
DOI ADDRESS
http://doi.org/10.25135/rnp.354.2207.2510
(DOI number will be activated after the manuscript has been available in an issue.)
STATISTICS
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AUTHORS
  • Ju-Tao Wang
  • Lan Ding
  • Ren-nai Yang
  • Liang-ping Zha
  • Yang Yu
  • Shuang-ying Gui
PDF OF ARTICLE

GRAPHICAL ABSTRACT


ABSTRACT


 A novel β-carboline, namely Plagranline A (1), and a known alkaloid (2) were isolated from the roots of Platycodon grandiflorus. Their structure was elucidated using a combination of spectroscopic analyses and computational chemistry, including electronic circular dichroism (ECD) and optical rotatory dispersion (ORD). Alkaloids 1 and 2 exhibited moderate inhibitory effects against NO production. Interestingly, 1 and 2 are the first alkaloid constituents reported from the plant P. grandifloras.

KEYWORDS
  • Platycodon grandiflorus
  • β-carboline
  • computational chemistry
  • alkaloid
  • anti-inflammatory activity

SUPPORTING INFORMATION


Supporting Information
Download File 354-RNP-2207-2510-SI.pdf (2.01 MB)