JOURNAL 3409
Records of Natural Products
VOLUME & ISSUE
Available Online: May 25,2025
Available Online: May 25,2025
PAGES
p.1 - 6
p.1 - 6
DOI ADDRESS
http://doi.org/10.25135/rnp.513.2501.3409 (DOI number will be activated after the manuscript has been available in an issue.)
http://doi.org/10.25135/rnp.513.2501.3409 (DOI number will be activated after the manuscript has been available in an issue.)
STATISTICS
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Viewed 107 times.
GRAPHICAL ABSTRACT
ABSTRACT
Chemical investigations of Platycodon grandiflorus have resulted in the isolation and identification of seven 8,4'-oxyneolignans, including four undescribed compounds (1-4). The structures of these novel compounds were determined using HR-ESI-MS and NMR (1D and 2D) spectroscopic analyses, combined with ECD calculations. The inhibitory activity of these terpenoids against α-glucosidase was also evaluated, and the results revealed that none of the compounds exhibited significant α-glucosidase inhibitory activity at a concentration of 50 μM. Compared with the positive control, all the compounds displayed weak inhibitory activity, with inhibition rates ranging from 1.06% to 7.31%.
KEYWORDS- Platycodon
- Platycodon grandiflorus
- apha-glucosidase
- chemical constituents
- 8,4-oxyneolignan.
