JOURNAL 779


Organic Communications
VOLUME & ISSUE
Year: 2016 Issue: 1 January-March
PAGES
p.1 - 18
STATISTICS
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AUTHORS
    Srinivas Avula, Sunitha Malladi and Rajesh Kumar Gaddam
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GRAPHICAL ABSTRACT


ABSTRACT


The stereoselective synthesis of the (C1-C24) fragment of Antanapeptin–A is described. The required stereochemistry of b -hydroxy- a -methyl acid unit was accomplished through Aldol reaction using Evans’ chiral auxiliary followed by the installation of terminal alkyne with Ohira–Bestmann reagent.

KEYWORDS
  • Antanapeptin A
  • Aldol Reaction
  • Stereo selective synthesis
  • Peptide
  • Evans’ auxiliary