JOURNAL 800


Organic Communications
VOLUME & ISSUE
Year: 2017 Issue: 1 January-March
PAGES
p.40 - 45
STATISTICS
Viewed 1405 times.
AUTHORS
    Brent A. Banasik
PDF OF ARTICLE

GRAPHICAL ABSTRACT


ABSTRACT


A simple and efficient method for the synthesis of biotin pre-functionalized linkers via orthogonal protecting group elongation strategy is reported for a single-step preparation of new biosensor probes. The target compound 4- (4- (4- (5- ((3S, 4S, 6R)-2-oxohexahydro-1H-thieno[3,4]imidazol-4-yl) pentanamido) butanamido) butanamido) butanoic acid (5) was synthesized in five linear steps with a 40% overall yield.

KEYWORDS
  • biosensor
  • linker
  • biotin
  • lagunamide

SUPPORTING INFORMATION


Supporting Information
Download File 7-OC-1612-451-SI.pdf (319.89 KB)