Synthesis and antibacterial activity of 2-amino chromenes arising cyanoiminocoumarins and β-naphthol
Year: 2017 Issue: 1 January-March
p.32 - 39
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Lamia Dammak, Mariem Kammoun, Noureddine Allouche, Houcine Ammar and Souhir Abid
The synthesis of 2-amino chromene, reported in our previous paper, has been accomplished by the reaction of cyanoiminocoumarin and β-naphthol . The obtained compound was reacted with various electrophilic or nucleophilic reagents. All the new homologous 2-amino-4H-chromenes have been characterized on the basis of their spectral (IR, 1H and 13C NMR) data and microanalysis. Four compounds were evaluated in vitro for their preliminary antibacterial activities against five different pathogenic bacterial strains such as Bacillus thuringiensis , Escherichia coli , Staphylococcus aureus, klebsiella pneumonia and Salmonella Sp . Antibacterial activity of each compound was compared with standard drug, Penicillin.KEYWORDS
- antibacterial activity