JOURNAL 797


Organic Communications
VOLUME & ISSUE
Year: 2017 Issue: 1 January-March
PAGES
p.15 - 23
STATISTICS
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AUTHORS
    Taner Gokcen, Melike Al , Meryem Topal, Ilhami Gulcin, Turan Ozturk and Ahmet C. Goren
PDF OF ARTICLE

GRAPHICAL ABSTRACT


ABSTRACT


Carbonic anhydrase inhibitors are both in clinical use as antiglaucoma, diuretics, antiepileptics and management of altitude sickness, and under investigation as anticancer, anticonvulsant and antiobesity agents. Sulphonamides have been known for decades as carbonic anhydrase inhibitors and are in clinical use. Sulphonamide derivatives of p-hydroxybenzoic acid and 3,4,5-trihydroxybenzoic acid (gallic acid) were synthesized and their inhibition values over hCA I and hCA II isozymes, purified from human erythrocyte cells by Sepharose-4B-L-tyrosine-sulphanilamide, were determined. Compounds synthesized showed efficient carbonic anhydrase inhibition activity at low nM levels.

KEYWORDS
  • Carbonic anhydrase inhibitor
  • sulphonamides
  • p-hydroxybenzoic acid
  • 3
  • 4
  • 5-trihydroxybenzoic acid (gallic acid)

SUPPORTING INFORMATION


Supporting Information
Download File 4-OC-1605-418-SI.pdf (1.52 MB)